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The transition from simple steatosis to advanced liver disease is governed by a multi-parallel hit model against this backdrop of established insulin resistance

A separate, higher-dose FDA-approved semaglutide is covered to reduce the risk of heart attack and stroke but only for people with established cardiovascular disease who also have obesity or are overweight with related conditions

Gerhards LJ, van Arnhem AC, Holman ND, Nossent GD

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Neuropharmacology 108:238251 Calabrese V et al (2010) Cellular stress responses, mitostress and carnitine insufficiencies as critical determinants in aging and neurodegenerative disorders: role of hormesis and vitagenes

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