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Moreover, betaine prevented the liver from ethanol-induced steatosis in rats by increasing the hepatic SAM levels ( Hyperhomocysteinemia is known to induce ER stress, which can activate sterol regulatory element-binding proteins (SREBPs) and upregulate enzymes in lipid synthesis, contributing to triglycerides and cholesterol accumulation and also induces apoptosis (Kaplowitz and Ji, 2006

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10.2337/diab.44.9.1126 21

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Sounds trivial until you do it for a year

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