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Where the field goes next The EVOKE/EVOKE+ results reinforce that singlemechanism interventions may not be sufficient to modify Alzheimers course in symptomatic stages

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For example, a dual synergistic nanoreactor incorporating dihydroquercetin and platinum nanocatalysts within mannose-modified OL-NP demonstrated robust neuroprotection by reducing neuronal injury and modulating microglial activation toward an anti-inflammatory M2 phenotype [299]