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J Pain Symptom Manage 42:788804 Kroly N, Mihly A, Dob E (2011) Comparative immunohistochemistry of synaptic markers in the rodent hippocampus in pilocarpine epilepsy

This concern relates to a common physiological principle known as down-regulation , where the body reduces its sensitivity to a hormone when it receives a strong external signal for an extended period

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This can make it difficult to solve the problem unless you catch it early on, which is what many B12 injections aim to do

Skin results may take several sessions

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