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Similarly, in zebrafish hatchlings exposed to a maximum concentration of 50 g/ml of CitAgNPs the hatchlings displayed normal developmental milestones, including hatching, appendage development, and the emergence of vital structures like nerves, eyes, and heart, indicating the absence of developmental toxicity

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Thyroid concerns arose during drug development due to C-cell hyperplasia and medullary thyroid carcinoma seen in rodent studies