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The genetic factors are primarily hereditary and non-modifiable, while the environmental factors are modifiable

Appl Biochem Biotechnol 174(8):28512863 Pandurangan M, Veerappan M, Kim DH (2015) Cytotoxicity of zinc oxide nanoparticles on antioxidant enzyme activities and mRNA expression in the cocultured C2C12 and 3T3-L1 cells

On the other hand, the combination of IKE and 5-FU showed a stronger antitumor effect, reducing tumor volume by approximately 0.15-fold, corresponding to approximately 85% inhibition relative to the control group

Therefore, we posit that this differential pharmacological properties may account for the observed discrepancy in experimental outcomes between the in vitro phagocytosis assays and in vivo tumor suppression models

PMCID: PMC5854864