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Microglia exhibiting neuroinflammatory signatures expanded with disease progression (such as GPNMB, THEMIS, PVALB , and WIF1 )

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First, its facultative anaerobic supports rapid proliferation in the intestinal tract, robust tolerance to gastric acid and bile, and production of bioactive substances such as antimicrobial peptides, B vitamins, and organic acids [71, 72]

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