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As a mitigation strategy, if the test for period effect post unblinding was significant, then the statistical model for the primary outcome had to be recomputed only on the data from the first period of the trial (where period effect is taken out)as recommended by clinical practice ( The test indicated a significant period effect ( p 3.0.co;2-7, 40

Allergy risk is very low, but not zero

To confirm that the toxicity was due to depletion of GSH, we supplemented 2-AAPA treated zoospores with either GSH or GSSG (6)