Therefore, the optimal animal model for DPD studies awaits further investigation and clinical evidence
Current findings suggest that inhibition of ferroptosis is likely to be an effective therapeutic approach in patients with epilepsy
Meltzer-Brody S, et al
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doi: 10.3389/fped.2023.1212405 Received 26 April 2023 Accepted 03 July 2023 Published 27 July 2023 Volume 11 - 2023 Edited by Massimo Zeviani, University of Padua, Italy Reviewed by Carlo Fiore Viscomi, University of Padua, Italy Muhammad Ikram Ullah, Jouf University, Saudi Arabia Updates Copyright 2023 Wu, Jiao, Xia, Yan, Liu, Cao and Ma
Inhibition of key ferroptosis regulators like acyl coenzyme ACSL4, GPX4, and Nrf2 may lead to unintended consequences, including disruptions to cellular homeostasis, thereby posing potential risks to therapeutic safety