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Titulacin de dosis: se empieza con una dosis conservadora y se ajusta hacia arriba en las primeras 8 a 12 semanas segn respuesta y tolerancia

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PDI is S-nitrosylated in lumbar spinal cords of sporadic ALS patients (Walker et al., 2010), which abrogates PDI-mediated attenuation of neuronal cell death triggered by ER stress or misfolded proteins (Uehara et al., 2006)

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