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Unlike broader-spectrum GHSs, ipamorelin targets the growth hormone secretagogue receptor (GHSR) with high specificity, with preclinical models showing minimal impact on ACTH or cortisol [peptidedosages.com]
90,91 Moreover, epidemiologic studies of different institutions showed that individuals with regular exercise, healthy diet (including more soluble fiber, colorful fruit, vegetables, green tea, or less intake of added sugars, carbs, trans-fats), limiting alcohol intake, avoiding smoking cigarettes and reduced levels of stress, which indeed increase insulin sensitivity
124,129 A common combination is GLP-1 with GIP or insulin-like growth factor
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