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Thats why your liver is packed with antioxidant machinery

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10.1093/eurheartj/ehad152 35 De MeyerG

Underpinning this crosstalk is metabolic reprogrammingsuch as enhanced glycolysis in macrophages and increased polyunsaturated fatty acid (PUFA) synthesis in epithelial cellswhich supplies the substrates necessary for both ferroptosis and immune activation, closing a vicious cycle

A previous study found that abnormally up-regulated transferrin and ferritin in the ovaries of naturally aging rats can cause iron-accumulating oxidative stress and inflammatory aging through the NF-B signaling pathway (43)

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