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GPR119 agonist AS1269574 activates TRPA1 cation channels to stimulate GLP-1 secretion

The combined result is a potent and sustained reduction in appetite and caloric intake that has been consistently demonstrated across large-scale clinical trials

Nature 609 , 801807 (2022)

Inflammatory states includes systemic lupus erythematosis, rheumatoid arthritis, and malignancies like hepatocellular carcinoma

Handbook of Developmental Cognitive Neuroscience, 2 , 553-574

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