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This happened for two reasons: Its real performance was already near the top

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If a vial has accidentally been frozen, it should not be used, even if it looks fine

The affected area may feel firm or rubbery under the skin

The variability in trial durations, ranging from 3 to 12 weeks across the included studies, and differences in the number of titration steps for each drug may further influence the reported incidence of gastrointestinal adverse events, particularly for agents like tirzepatide, where nausea risk escalates with higher doses (e.g., OR = 4.36, 95% CI: 3.425.61 at 10 mg) (Liu et al., 2025)

Trulicity is administered subcutaneously (under the skin) into fatty tissue, typically in the abdomen, thigh, or upper arm (if administered by someone else)