Based on its unique functions, GPX4 is considered a powerful antagonist of ferroptosis and plays a crucial role in regulating ferroptosis
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This leads to the cleavage and translocation of AIF from the mitochondrial intermembrane space to the nucleus, phosphorylation of the histone H2A family member H2AX, mitochondrial release of the death-inducing protein Smac/direct IAP-binding protein with low PI (DIABLO), and inhibition of the anti-apoptotic protein X-linked inhibitor of apoptosis (XIAP)
Rand EED, Smit S, Beukes M, Apostolides Z, Pirk CWW, Nicolson SW
Xu J, Zhu K, Wang Y, Chen J
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