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While mild infections were characterized by highly activated HLA-DR hi CD11c hi inflammatory monocytes with the interferon-stimulated gene (ISG) signature, severe illness was manifested by dysfunctional neutrophil precursors, and HLA-DR lo monocytes with pro-inflammatory functions ( While global vaccination campaigns are underway, the development of efficient therapies to prevent COVID-19 disease progression is an urgent need

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Many endocrine and neuroendocrine axes are peptide-driven