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Therefore, targeting the System Xc /GSH/GPX4 axis while minimizing side effects represents a major ongoing challenge and a key direction for future PDAC therapy

References 1 BlumWFAlherbishAAlsagheirAEl AwwaAKaplanWKoledovaEet al

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The primary cause is the ROS-induced accumulation of LIP in acute myeloid leukemia cells (173)