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This explains why intracellular oxidation kinetics for roGFP2 fusion constructs with glutaredoxin mutants showed excellent correlation with the second order rate constants of the oxidative half-reaction from in vitro experiments 15,26,34,35

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Cell cycle arrest and chronic inflammation Senescent cells are characterized by irreversible cell cycle arrest, triggered by senescence-associated stressors, including DNA damage responses (DDRs) induced by oxidative stress, ROS, smoking, poor nutrition, oncogenes, gut microbiota, and mitochondrial dysfunction

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