Tirzepatides site of action in the arcuate nucleus involves binding to GLP-1 receptors on POMC/CART neurons(anorexigenic pathway)
But the commercial implications are already attracting serious attention because GLP-1s appear to affect far more than appetite
Lonza has established the safety and tolerability profile of L-carnitine tartrate in humans at a daily dose of up to 3 g (equivalent to 2 g elemental L-carnitine)
Palanca A et al, Real-World Evaluation of GLP-1 Receptor Agonist Therapy Persistence, Adherence and Therapeutic Inertia Among Obese Adults with Type 2 Diabetes
Figure 2: Paul Stamets with Lions Mane (left) the author with Hen of the Woods, Griffola frondusa (right)
Most people have no issue with this, but if you have a known sensitivity to sulfur-rich foods (like garlic, onions, or cruciferous vegetables), you might notice mild digestive shifts or a general feeling of "heaviness" when you start