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This comprehensive study, which included eight studies comprising 73,981 participants, showed a trend toward increased breast cancer risk in carriers of HFE variants, particularly C282Y homozygotes (odds ratio = 1.36, 95% confidence interval = 0.751.98)

1,000 to 1,200 mg daily, based on body weight less than or greater than 75 kg (it has been recently suggested that the heaviest patients could even benefit from a higher ribavirin dose, up to 1,600 mg daily) and they theoretically require 48 weeks of treatment (Figure 1A) [18 ]