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Prediction-corrected visual predictive check (VPC) plots were used to assess the predictive performance of the final model

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doi: 10.1056/NEJMra043430

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(Jastreboff et al., NEJM, 2022) The 2025 head-to-head SURMOUNT-5 trial confirmed tirzepatide's superior metabolic effect across multiple endpoints in non-diabetic patients with obesity