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7 Despite the growing evidence of the CV benefits of GLP-1 RAs and dual glucose-dependent insulinotropic polypeptide (GIP) receptor agonists/GLP-1 RAs in T2D patients and their inclusion in guidelines, lack of awareness of the CV benefits of GLP-1 RAs and dual GIP/GLP-1 RAs, clinical inertia, resistance to injectable medications and concerns about treatment costs have hindered the widespread adoption of GLP-1 RAs

The real picture is more nuanced than either "GLP-1s are destroying your muscle" or "muscle loss isn't really a thing." Here's what the accumulating evidence from 2024 through 2026 actually shows

[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Nikolaidis LA, et al

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This is fine while you get your symptoms under control, and you can widen the variety of your diet as your symptoms ease

Metabolic optimization reduces pancreatic stress