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In the absence of NAD+, reduced deacetylation of NF-B by Sirt1 initiated the transcription of pre-apoptotic factor NLPR3, which ultimately led to the increase in inflammasome and the induction of age-related inflammatory factors expression [23]

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GLP-1R agonists such as semaglutide, tirzepatide, and mazdutide not only promote insulin secretion, suppress appetite, and delay gastric emptying, thereby effectively reducing body weight, but also help improve lipid profiles and reduce the risk of cardiovascular diseases

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Daniels, B., Havard, A., Myton, R., Lee, C