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Rare : Allergic reactions, including rash or swelling

GHK-Cu Peptide Synthesized and Lyophilized in Canada by Koi Peptides Domestic Synthesis at a Canadian Facility Synthesis of the Gly-His-Lys tripeptide is carried out by solid-phase peptide chemistry at a Canadian production partner, with copper coordination introduced as a separate complexation step against the purified free peptide

(multiple publications, 1990s-2020s)

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Tolerability (preclinical): Each peptide is generally well tolerated in animal studies, with occasional mild injection-site reactions