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Jardiance is recommended by the National Institute of Clinical Excellence (NICE) as a treatment for type 2 diabetes under the following conditions: When diet and exercise do not provide adequate glycemic control When metformin is not appropriate due to patient intolerance Jardiance is also recommended alongside metformin if a patient is at significant risk of hypoglycemia or cannot take a sulfonylurea
The patients initial presentation of hyponatremia diverted attention from her primary complaint of unsteadiness, resulting in delayed evaluation of the underlying neurological cause
Future RCTs should adopt the NIHNINDS Common Data Elements for DN, pre-specify subgroup analyses based on glycaemic control and medication use, and employ adaptive or platform designs to achieve adequate power while accounting for heterogeneity
