glp-1 news november 2025 The expanding landscape of medicines GLP-1 Pipeline Update: November 2025

PT-141 takes a different approach, working in the brain where desire actually starts

Trigger factors in migraine patients

Exp Mol Pathol 92:126130 Lu SC, Ramani K, Ou X, Lin M, Yu V et al (2009) S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model

doi: 10.1146/annurev-physiol-020518-114640

It is more likely to cause gastrointestinal side effects, including diarrhea, and may be less efficient at raising serum magnesium levels

This conversion creates a recycling pathway known as the citrulline-NO cycle, where NOS (nitric oxide synthase) enzymes transform L-arginine into NO and L-citrulline