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For a comprehensive review of the anti-obesity effects of GLP-1RAs, which is beyond the purpose of this article, see ref

New developments, such as dual and triple agonists that target the glucagon, GLP-1, and GIP receptors, promise better results

Important safety considerations include the risk of pancreatitis (seek urgent medical attention for severe, persistent abdominal pain), gallbladder disease, and dehydration or acute kidney injury from severe gastrointestinal symptoms

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combining three or more signs improved sensitivity to approximately 87% [9]