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These limitations primarily stem from systemic toxicity, poor pharmacokinetics, and inadequate tumor penetration, compounded by the metabolic plasticity of cancer cells [28, 29]

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In this model, DES is induced by exposure of the animals to general anesthesia, which diminishes the production of basal and reflex tears and decreases the stability of the tear film thereby inducing common signs of the disease [4,28]

doi: 10.1210/me.2011-1037 186 ChenZWangYWardenCChenS

Luteinizing hormone regulates testosterone production, Leydig cell proliferation, differentiation, and circadian rhythm during spermatogenesis