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Cutting protocol considerations: Start titration 4-8 weeks before your target cut begins so you are at working dose when the serious deficit starts Set a caloric floor below which you will not drop regardless of how suppressed your appetite becomes

When waste moves slowly, the colon has more time to absorb water from it

In our blog, Microdosing GLP-1 Medications: A Gradual Approach to Weight Loss, we discuss how gradual dose adjustments may help some patients minimize side effects while still making progress

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JAMA Netw Open 7(7):e2421305e2421305 Emerenziani S, Pier Luca Guarino M, Trillo Asensio LM, Altomare A, Ribolsi M, Balestrieri P, Cicala M (2019) Role of overweight and obesity in gastrointestinal disease

Dehydration not only worsens these symptoms but can also interfere with how well the medication works