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From this information, they developed a remediation plan to resolve the issues that resulted from the adverse reaction to the injection

BDOC (Biodegradable Dissolved Organic Carbon) The portion of dissolved organic carbon in water that can be metabolized by microorganisms in BAC filters

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Abbreviations TDM: Therapeutic drug monitoring LC: Liquid chromatography UV: Ultra-violet MS: Mass spectroscopy TMS: Tandem mass spectrometry LC-MS: Liquid Chromatography-Mass Spectroscopy HPLC: High-Performance Liquid Chromatography AUC: Area Under Curve PK: Pharmacokinetic AAG: Alpha 1-acid glycoprotein CYP450: Cytochrome P450 ABC: ATP-Binding cassettes MTX: Methotrexate HPLC-UV: High Performance Liquid Chromatography-Ultraviolet FLD: Fluorescence detection DDE: 1,1-(o, p-dichlorodiphenyl)-2,2 dichloroethene DDA: 1,1-(o, p-dichlorodiphenyl) acetic acid 5-FU: 5-fluorouracil SERS: Surface Enhanced Raman Spectroscopy 6-MP: 6-mercaptopurine TLC: Thin Layer Chromatography LLE: Liquid-liquid extractions SPE: Solid phase Extraction ACN: Acetonitrile DPD: dihydro pyrimidine dehydrogenase HSCT: hematopoietic stem cell transplantation NGS: Next-generation sequencing PET: Positron Emission Tomography MRI: Magnetic Resonance Imaging DNA: Deoxyribonucleic acid RNA: Ribonucleic acid HDMTX: High-dose Methotrexate PG-3: Polyglutamate-3 mAbs: Monoclonal antibodies PPCs: Plasma posaconazole concentrations References Wilkinson DS