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This is the case of transferrin receptor (TfR) and low-density lipoprotein receptor (LRP1) which serve as common molecular targets on brain endothelial cells exploited by nanoparticles to enable transcytosis ( via glucose transporter-1 (GLUT1), a key mediator of cerebral glucose uptake

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Together with zinc, they catalyse the rearrangement of dopachrome to 5,6-dihydroxyindole-2-carboxylic acid in the final phase of eumelanin formation in melanogenesis [101, 102]

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