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It is now understood that the three processes above mentioned alter the native non-covalent polypeptide interactions of complex I and promote synergistically protein damage and inactivation by shifting the noncovalent bonding to covalent cross linking (Navarro et al., 2005)

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11 were in the final stages of clinical trials as of June 2024 [112] Among others, Hangzhou Jiuyuan Gene Engineering, The United Laboratories, CSPC Pharmaceutical Group, Huadong Medicine (which also holds a majority stake in Jiuyuan Gene [115] ) and Sihuan Pharmaceutical were all preparing generic offerings

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Front Immunol 7:154 Zietek T, Waldschmitt N, Rath E (2017) Role of incretin hormones in bowel diseases