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The synergistic insulin secretion produced by simultaneous GIP and GLP-1 receptor activation is mechanistically distinct from what amylin/GLP-1 combinations provide, and the SURPASS trial data in diabetic populations is among the strongest in the field

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Last accessed November 13, 2024

From a prospective perspective, future research should prioritize adequately powered, multicenter randomized trials that standardize vitamin D, C, and E dosing regimens, treatment duration, and core outcome sets, including pain, quality of life, biomarker, and fertility endpoints