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Peptides have been used therapeutically for a century, since researchers discovered insulins potential to treat type 1 diabetes

Anticancer chemotherapeutic agents, when taken for long-term therapy, have been reported to cause many side effects such as cardiotoxicity, lung toxicity, testicular toxicity, and hepatotoxicity

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When the iron load increases (such as high iron reserve level, high serum iron) 25 or in cases of infection and chronic inflammation, 26 elevated hepcidin directly binds to membrane FPN, promoting its internalization as well as degradation in epithelial cells of intestinal, thereby inhibiting iron absorption into the blood