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In head-to-head studies, Retatrutide led to greater weight loss , better liver fat reduction , and higher energy expenditure

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This hormone signals by binding to and activating GCGR, which is a G protein-coupled receptor primarily expressed by hepatocytes in the liver

These methodological limitations temper the strength of the conclusions and preclude a quantitative synthesis, highlighting the urgent need for prospective, dedicated ophthalmic RCTs