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GLP-1 receptor activation enhances glucose-dependent insulin secretion, suppresses inappropriate glucagon release, slows gastric emptying, and reduces appetite through central nervous system effects
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In summary, the relatively higher expression of GLP-1R on -cells allows GLP-1 to indirectly inhibit glucagon secretion by promoting somatostatin secretion
Rather than overriding the system, peptide therapy attempts to re-engage it
Consult your doctor immediately if these side effects persist or worsen
