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Contact healthcare provider for dose adjustment if severe constipation occurs

doi: 10.1016/j.autrev.2020.102647 169 SchneiderALongSACerosalettiKNiCTSamuelsPKitaMet al

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Drug molecules and activated form of glucuronic acid are present in the cytosol while UGT is present in SER so drug molecules and UDPGA are transferred to SER where glucuronic acid conjugation occurs and metabolite/conjugated product is transferred to the cytoplasm [10]

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These dilemmas included the inability to determine the extent of disease with the standard workup, unclear ER status of the tumor, or the inability to determine which primary tumor caused the metastases