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These changes were accompanied by inflammatory alterations in the intestinal mucosa and elevated levels of lipopolysaccharides (LPS), which activate TLR4-dependent inflammatory pathways and contribute to -cell damage (Vatanen et al., 2018)

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The STEP 5 trial confirmed that at 2 years, weight loss stabilized at -15.2% from baseline meaning the body reaches a new set point where caloric intake and expenditure balance out (Garvey et al., 2022)

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IV use at appropriate infusion rates has not shown the same risk profile, but medical history review is standard Individuals with a known sensitivity to sulfur-containing compounds should inform their provider High-dose IV glutathione for cosmetic skin lightening, particularly in unregulated settings, has been associated with adverse events including anaphylaxis and reports of hepatotoxicity