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Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: Reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse

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Equally unresolved is how redox thresholds are established namely, when GSH-mediated buffering shifts from protective to permissive for cell death, and how changes in NADPH availability, metal speciation, or mitochondrial dependence reprogram this balance