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When this conversion is impaired due to reduced methylfolate, homocysteine accumulates in the blood, causing inflammation and oxidative stress in blood vessels
Berk M, Plein H, Ferreira D: Platelet glutamate receptor supersensitivity in major depressive disorder
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This suggests the PHB-ANXA2 system has multiple roles in fat biology, and FTPP may be affecting more pathways than just the obvious vascular destruction
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