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The study objectives and protocol were carefully explained to the subjects and their written informed consent was obtained

Jpn Med Assoc J 124(11):15491553 Squadrito GL, Pryor WA (1998) Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide

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Nevertheless, treatment with semaglutide demonstrated to improve HF related symptoms in non-diabetic patients with HFpEF, and a recent meta-analysis encompassing eight trials and 60,080 patients demonstrated an overall reduction of HF-related hospital admission by 11% [115, 124]