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[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Knop FK, et al

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In light of the narrow therapeutic window defined by the balance between glucose-lowering efficacy and (so-called) gastrointestinal side effects, it seems unlikely that future long-acting GLP-1 receptor agonists will provide substantially greater efficacy without inducing more side effects compared with the already available compounds