labial melanotic macule causes Pigmented lesions of the oral cavity: An Update Labial melanotic macule. B). Increased

Any perturbation in the balance in the level of antioxidants and the reactive species results in a physiological condition called oxidative stress. A catalase is one of the crucial antioxidant enzymes that mitigates oxidative stress to a considerable extent by destroying cellular hydrogen peroxide to produce water and oxygen

For instance, dietary serine and glycine limitation or use of ketogenic diet effectively inhibited tumour growth in several models 40,41,42

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Concomitant use of dipeptidyl-peptidase-4 inhibitors (DPP-4) is not recommended because they have a similar basis of action