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From a reproductive endocrine perspective, canonical PCOS is characterized by: (i) hyperandrogenism, presenting as hirsutism, acne, and androgenetic alopecia, with elevated total/free testosterone, an increased free androgen index (FAI), and occasionally elevated dehydroepiandrosterone sulfate (DHEAS)

Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity

Caspase 9 then cleaves and activates pro-caspase-3, leading to the commencement of the cell death program, commonly known as the apoptosis cascade [24]

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Methylation cycle cofactor: Vitamin B6 is a cofactor in the methylation cycle and is important for balancing homocysteine levels