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FEBS Letters , 238(2), 343346

While reducing USP7 activity via RNA interference or pharmacological inhibition lengthened circadian period in MEFs and U2OS cells (Papp et al., 2015), other studies reported the opposite effect, with knockdown shortening and overexpression lengthening the period (Hirano et al., 2016)

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Experimental results showed a modulation interaction of DSIP with endogenous opioid-peptidergic systems and exogenous intracerebrally or systemically administered morphine and amphetamine