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The within-individual variation from dose to dose in oral semaglutide bioavailability was relatively high, but as a result of daily dosing and a long plasma half-life (1 week), the variability of semaglutide exposure at steady state was considerably reduced

Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts

As a GLP-1 receptor agonist, semaglutide mimics glucagon-like peptide-1, a natural hormone your body releases after eating

Also, storing semaglutide vials or pens near a window with direct sunlight exposure can lead to quick temperature increases that jeopardise its stability

This can increase the chances of leg cramps, particularly during physical activity or at night when blood flow naturally slows down

Discuss them with your healthcare provider during follow-up sessions, and they will adjust the dose accordingly