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Pharmacological interventions through the use of NOX inhibitors, including diphenyleneiodonium and GKT137831, have demonstrated that inhibiting NOX4 can substantially reduce ROS levels and lipid peroxidation, and thus protect against ferroptosis (109,110)

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Introduction Liver dysfunction leads to metabolic disorders and ultimately endangers personal health ( NAFLD is a chronic progressive lesion involving in inflammation, oxidative stress, insulin resistance, and imbalances in lipid metabolism ( Several studies have demonstrated that ferroptosis plays a crucial role in the occurrence of NAFLD ( Ferroptosis and non-alcoholic fatty liver disease/non-alcoholic fatty liver disease-hepatocellular carcinoma Ferroptosis Ferroptosis is a non-apoptosis with a completely different morphology

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