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However, early tBHQ research demonstrated that the addition of tBHQ increases NRF2-mediated transcription and confers neuroprotection from glutamate-induced oxidative damage (Shih et al., 2003

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Nonetheless, because autism is inuenced by multiple interacting genetic and environmental factors that are case-specic and inherent limitations in post-mortem brain, these observations will require conrmation in subsequent studies