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Advise patients that substantial or rapid weight loss can increase the risk of gallbladder disease, but that gallbladder disease may also occur in the absence of substantial or rapid weight loss

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Assuming a 50% price erosion post-generic entry and 50% market share capture by generics, the addressable opportunity could be around USD 500 million

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In a large systemic review and network analysis, including several GLP-1RAs, subcutaneous semaglutide was the only glucose-lowering drug for which this signal was observed (120)

This is a direct consequence of slowed gastric emptying and increased gastrointestinal transit time