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We definitely want patients to do their part with the diet and exercise, but unfortunately, and from a practical standpoint, that itself frequently is not enough, Hong said, adding that usually by the time patients see doctors, they have failed at achieving results through those means

SURMOUNT-1 (Jastreboff et al., NEJM 2022) reported 22.5% body weight loss at 72 weeks at the 15 mg dose

This result is clinically significant for three reasons

Ceramides help maintain epidermal integrity and barrier function

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